ZytoLight® SPEC BCOR Dual Color Break Apart Probe

The ZytoLight® SPEC BCOR Dual Color Break Apart Probeis designed to detect rearrangements involving the chromosomal region Xp11.4 harboring the BCOR gene.

In the 2020 WHO classification of soft tissue and bone tumors, BCOR-rearranged sarcoma is recognized as a distinct entity due to particular morphological, immunohistochemical, and molecular features and differing clinical outcomes compared to other undifferentiated sarcomas.

There are considerable overlapping morphological and immunohistochemical features with classical Ewing sarcoma, other subtypes of small round cell tumors, as well as lymphomas and carcinomas. Therefore, the evaluation of the BCOR rearrangement status by FISH may be of diagnostic relevance.